Nucleoside Analogs. 4. Synthesis of 3′-Amino-3′-deoxyadenosine Analogs
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چکیده
منابع مشابه
A Direct Synthesis of Nucleoside Analogs Homologated at the 3 - and 5 -Positions
A new route is presented to prepare analogs of nucleosides homologated at the 3 and 5 -positions. This route, applicable to both the and -enantiomeric forms, is suitable for the preparation of monomeric bishomonucleosides needed for the synthesis of oligonucleotide analogs. It begins with the known monobenzyl ether 3 of pent-2-yne-1,5-diol, which is reduced to alkenol 4. Sharpless asymmetric ep...
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Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new Nand C-nucleosides is presented. In the second part, the discovery of aromatic polycyclic derivatives as inhibitors of Tat protein is exposed. The work presented takes into account the partic...
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A wide variety of purine nucleoside (mainly tubercidin and adenosine) analogs, which had previously been shown to inhibit the replication of a broad spectrum of RNA viruses, were evaluated for their antirhinovirus activity in human diploid (WI-38) fibroblasts. Tubercidin, 5-(1-hydroxyethyl)tubercidin, 5-(2-buten-1-yl)tubercidin, toyocamycin, and sangivamycin emerged as the most potent inhibitor...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1977
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.50.1572